Host protection by two memory-like MAIT subsets.
Dominguez-Villar M.
HERV1-env induces unfolded protein response activation in autoimmune liver disease: a potential mechanism for regulatory T cell dysfunction.
Subramanian K, Paul S, Libby A, Patterson J, Arterbery A, Knight J, Castaldi C, Wang G, Avitzur Y, Martinez M, Lobritto S, Deng Y, Geliang G, Kroemer A, Fishbein T, Mason A, Dominguez-Villar M, Mariappan M, Ekong UD.
J Immunol
Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19.
Maher AK, Burnham KL, Jones EM, Tan MMH, Saputil RC, Baillon L, Selck C, Giang N, Argüello R, Pillay C, Thorley E, Short CE, Quinlan R, Barclay WS, Cooper N, Taylor GP, Davenport EE, Dominguez-Villar M.
Control of CD4+ T cell differentiation and function by PI3K isoforms.
Cameron C, Zaheer SA, Dominguez-Villar M.
Curr Top Microbiol Immunol
Distorted TCR repertoires define multisystem inflammatory syndrome in children.
Malik A, Tóth EN, Teng MS, Hurst J, Watt E, Wise L, Kent N, Bartram J, Grandjean L, Dominguez-Villar M, Adams S, Cooper N.
Fatty acid metabolism and T cells in multiple sclerosis.
Pompura SL, Hafler DA, Dominguez-Villar M.
TKT deficiency puts Tregs to rest.
Dominguez-Villar M.
Antigen-specific regulatory T cell therapy in autoimmune diseases and transplantation.
Selck C, Dominguez-Villar M
Front Immunol
Editorial: control of regulatory T cell stability, plasticity and function in health and disease.
Piconese S, Walker LSK, Dominguez-Villar M
Front Immunol
Oleic acid induces tissue-resident Foxp3 regulatory T cell function.
Pompura SL, Wagner A, Kitz A, LaPerche J, Yosef N, Dominguez-Villar M, Hafler DA
J Clin Invest (highlighted in The New England Journal of Medicine)
Modulation of regulatory T cell function and stability by co-inhibitory receptors.
Lucca LE, Dominguez-Villar M
Nat Rev Immunol
TLR7 and TLR8 activate distinct pathways during RNA virus infection.
De Marcken M, Dhaliwal K, Gautron AS, Dominguez-Villar M
Sci Signal
TIGIT signalling restores suppressor function of Th1-Tregs.
Lucca LE, Axisa PP, Singer ER, Nolan EM, Dominguez-Villar M, Hafler DA
JCI Insight
Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivo.
Dominguez-Villar M, Raddassi K, Danielsen AC, Guarnaccia J, Hafler DA.
J Autoimmun
Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity.
Sumida T, Lincoln MR, Ukeje CM, Rodriguez DM, Akazawa H, Noda T, Naito AT, Komuro I, Dominguez-Villar M, Hafler DA
Nat Immunol
Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivo.
Dominguez-Villar M, Raddassi K, Danielsen AC, Guarnaccia J, Hafler DA
J Autoimmun
Interactions between tumor associated macrophages and tumor cells in glioblastoma: unraveling promising targeted therapies.
Morisse MC, Jouannet S, Dominguez-Villar M, Sanson M, Idbaih A
Expert Rev Neurother
Regulatory T cells in autoimmune diseases.
Dominguez-Villar M and Hafler DA
Nat Immunol
The PI3K/AKT pathway on regulatory T cell development, function and stability.
Pompura S, Dominguez-Villar M
J Leukoc Biol
Molecular mechanisms underlying Th1-like Treg generation and function.
Kitz A, Dominguez-Villar M
Cel Mol Life Sci
Immune modulation by the hepatitis C virus core protein.
Fernández-Ponce C, Dominguez-Villar M, Muñoz-Miranda JP, Arbulo-Echevarria MM, Litrán R, Aguado E, García-Cozar F
J Viral Hepat
AKT isoforms modulate Th1-like Treg generation and function in human autoimmune disease.
Kitz A, de Marcken M, Gautron AS, Mitrovic, M, Hafler DA, Dominguez-Villar M.
EMBO Rep
Sensitivity of dendritic cells to NK-mediated lysis depends on the inflammatory environment and is modulated by CD54/CD226-driven interactions.
Smith LE, Olszewski MA, Georgoudaki AM, Wagner AK, Hägglöf T, Karlsson MC, Dominguez-Villar M, Garcia-Cozar F, Mueller S, Ravens I, Bernhardt G, Chambers BJ.
J Leukoc Biol
Nonapoptotic and extracellular activity of granzyme B mediates resistance to regulatory T cell (Treg) suppression by HLA-DR-CD25hiCD127lo Tregs in multiple sclerosis and in response to IL-6.
Bhela S, Kempsell C, Manohar M, Dominguez-Villar M, Griffin R, Bhatt P, Kivisakk-Webb P, Fuhlbrigge R, Kupper T, Weiner H, Baecher-Allan C
J Immunol
TLR7 induces anergy in human CD4+ T cells.
Dominguez-Villar M, Gautron AS, de Marcken M, Keller MJ, Hafler DA.
Nat Immunol (Recommended at F1000prime and highlighted in Nature Immunology News and Views)
Enhanced suppressor function of TIM-3+ FoxP3+ regulatory T cells.
Gautron AS, Dominguez-Villar M, de Marcken M, Hafler DA
Eur J Immunol
Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells.
Kofler DM, Marson A, Dominguez-Villar M, Xiao S, Kuchroo VK, Hafler DA
J Clin Invest
CD4+ primary T cells expressing HCV-core protein upregulate Foxp3 and IL-10, suppressing CD4 and CD8 T cells.
Fernandez-Ponce C, Dominguez-Villar M, Aguado E, Garcia-Cozar F
PLoS One
The TIGIT/CD226 axis regulates human T cell function.
Lozano E, Dominguez-Villar M, Kuchroo V, Hafler DA.
J Immunol
Up-regulation of FOXP3 and induction of suppressive function in CD4+ Jurkat T-cells expressing hepatitis C virus core protein.
Dominguez-Villar M, Fernandez-Ponce C, Munoz-Suano A, Gomez E, Rodriguez-Iglesias M, Garcia-Cozar F
Clin Sci (Lond)
The effects of hepatitis C virus core protein on functional responses in the NK cell line YTS.
Dominguez-Villar M, Garcia-Cozar FJ, Chambers BJ
Scand J Immunol
Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease.
Dominguez-Villar M, Baecher-Allan CM, Hafler DA
Nat Med (Recommended at F1000Prime and highlighted in Sci Transl Med Editor’s choice)
Immunology. An innate role for IL-17.
Dominguez-Villar M, Hafler DA.
Science
CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis.
Baecher-Allan CM, Costantino CM, Cvetanovich GL, Ashley CW, Beriou G, Dominguez-Villar M, Hafler DA
J Immunol
Serine residues in the LAT adaptor are essential for TCR-dependent signal transduction.
Martinez-Florensa M, Garcia-Blesa A, Yelamos J, Munoz-Suano A, Dominguez-Villar M, Valdor R, Alonso A, Garcia-Cozar F, Aparicio P, Malissen B, Aguado E
J Leukoc Biol
Droplet-based microfluidic platforms for single T cell secretion analysis of IL-10 cytokine.
Konry T, Dominguez-Villar M, Baecher-Allan C, Hafler DA, Yarmush ML.
Biosens Bioelectron
Concurrent overexpression of serum p53 mutation related with Helicobacter pylori infection.
Lopez-Saez JB, Gomez-Biondi V, Santamaria-Rodriguez G, Dominguez-Villar M, Amaya-Vidal A, Lorenzo-Penuelas A, Senra-Varela A
J Exp Clin Cancer Res
Chemosensitivity test on brain tumors.
Gil-Salu JL, Bosco-Lopez J, Dominguez-Villar M, Dominguez-Pascual I, Perez-Requena J, Palomo MJ, Lopez-Escobar M.
Neurocirurgia (Astur)
Metabolic profile of breast cancer in a population of women in southern Spain.
Lopez-Saez JB, Martinez-Rubio JA, Alvarez MM, Carrera CG, Dominguez Villar M, de Lomas Mier AG, Domenech C, Senra-Varela A.
Open Clin Cancer J
Regulation of NFAT by poly(ADP-ribose) polymerase activity in T cells.
Valdor R, Schreiber V, Saenz L, Martinez T, Munoz-Suano A, Dominguez-Villar M, Ramirez P, Parrilla P, Aguado E, Garcia-Cozar F, Yelamos J
Mol Immunol
Hepatitis C virus core protein up-regulates anergy-related genes and a new set of genes, which affects T cell homeostasis.
Dominguez-Villar M, Munoz-Suano A, Anaya-Baz B, Aguilar S, Novalbos JP, Giron JA, Rodriguez-Iglesias M, Garcia-Cozar F
J Leukoc Biol
PI3K isoforms and T cell function.
Zaheer SA, Cameron B, Dominguez-Villar M
Springer book on PI3K isoforms in immunity (In preparation)
Regulatory T cells as a therapy for autoimmune diseases.
Selck C, Dominguez-Villar M.
Chapter 5 (pages 33-46) of Hematopoietic stem cell transplantation and cellular therapies for autoimmune diseases.
Editor: Richard K Burt, CRC Press, Taylor & Francis Group